Senior Scientist - Therapeutic Modality Assessment for Surface Targets Job at Amgen, Thousand Oaks, CA

  • Amgen
  • Thousand Oaks, CA

Job Description

Amgen seeks a Senior Scientist to characterize cell-surface therapeutic targets and evaluate therapeutic modalities using quantitative experimental approaches. This early-stage validation role integrates proteomics and transcriptomics data to guide target prioritization and therapeutic strategy across disease areas.

Responsibilities

  • Propose and experimentally evaluate therapeutic modalities for surface targets based on target properties
  • Develop scalable, high-throughput quantitative workflows assessing protein degradation, internalization, trafficking, and cellular function
  • Integrate experimental findings into Go/No-Go decision packages guiding therapeutic modality selection
  • Collaborate across early validation team and functions to document workflows and present validated data

Requirements

  • Ph.D. in Cell Biology, Biomedical Science, Immunology, Oncology, Pharmacology, or related field; or Master's plus 2 years relevant experience; or Bachelor's plus 4 years relevant experience
  • 2+ years biotechnology or pharmaceutical industry research experience
  • Demonstrated contributions to discovery programs across multiple therapeutic modalities
  • Experience with early target validation, antibody/binder, or small-molecule characterization
  • Hands-on proficiency with flow cytometry or quantitative imaging for surface target measurement
  • Experience developing and executing high-throughput cell-based screening assays
  • Strong data analysis, problem-solving, and scientific communication skills

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